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Thus, the envisaged vascular defensive response is effective at any time with BPC 157 therapy [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25], and, upon injury, has been induced whatever the cause may be (ischemia or reperfusion), providing, also, the worst scenario of multiorgan injuries with the ischemia of intra-abdominal hypertension grade III and grade IV and its course thereafter, i.e., reperfusion after decompression